Method of enhancing self renewal of stem cells and uses thereof

Details Method of enhancing self renewal of stem cells and uses thereof Method of enhancing self renewal of stem cells and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12N 5/0789 (2010.01) A61K 35/28 (2006.01) A61K 48/00 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2409317

The present invention relates to methods for self renewal of stem cells. In particular the invention relates to stem cells of increased transplant potential or enhanced self renewal, stem cell cultures derived therefrom and uses of the stem cell cultures for treatment and particularly for transplantation and gene therapy protocols. In a first aspect of the present invention there is provided a stem cell which maintains functional capacity upon self renewal or cell division in culture. In another aspect of the present invention, there is provided a method of culturing self renewal stem cells to maintain or enhance functional capacity upon self renewal, said method comprising subjecting said stem cells to an effective amount of a retinoid or equivalent thereof or modulating expression and/or activity of an RAR or equivalent thereof in the stem cell.

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