Method of evaluating efficacy of nucleic acid therapy

Details Method of evaluating efficacy of nucleic acid therapy Method of evaluating efficacy of nucleic acid therapy

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 47/44 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 15/88 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2459373

A method of preliminarily evaluating the efficacy of a treatment with a nucleotide or a nucleoside having an antitumor or antiviral effect on individual patients as a pre-treatment for tailor-made therapy; medicinal compositions for the evaluation; a screening method for finding out a drug having an antitumor or antiviral effect; a method of searching for a function mechanism of an antitumor agent or an antiviral agent in vivo; etc. Namely, use is made as an indication of a change in the expression dose or activity of a protein relating mainly to any of the sequences represented by SEQ ID NOS: 1 to 4 before and after the administration of the nucleotide or nucleoside.

L'invention concerne une méthode d'évaluation préliminaire de l'efficacité d'un traitement dans lequel sont utilisés un nucléotide ou un nucléoside possédant un effet antitumoral ou antiviral sur des patients individuels en tant que prétraitement pour une thérapie personnalisée. L'invention concerne également des compositions médicinales d'évaluation, une méthode de criblage permettant de trouver un médicament possédant un effet antitumoral ou antiviral, une méthode de recherche d'un mécanisme fonctionnel d'un agent antitumoral ou d'un agent antiviral in vivo, etc.. L'invention est notamment utilisée pour indiquer un changement dans la quantité ou l'activité d'expression d'une protéine principalement associée à une quelconque des séances SEQ ID NOS 1 à 4 avant et après l'administration du nucléotide ou du nucléoside.

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