Method of examining pregnancy toxemia

G - Physics – 01 – N

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G01N 33/543 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2592527

It is intended to provide a method of detecting the onset of pregnancy toxemia whereby the onset risk of pregnancy toxemia can be adequately evaluated. Namely, a method of detecting the onset of pregnancy toxemia in a pregnant mammal which comprises the measurement step of measuring the concentration of angiopoietin-2 in a body fluid, the comparison step of comparing the angiopoietin-2 concentration obtained in the above measurement step with a normal level, and the judgment step of judging the presence or absence of the onset risk of pregnancy toxemia based on the results of the above comparison step. In the comparison step, it may be considered that the patient has a risk of the onset of pregnancy toxemia in the case where the angiopoietin-2 concentration obtained in the measurement step is lower than the normal level.

L'invention concerne une méthode permettant de détecter l'apparition de la toxémie gravidique et d'évaluer de manière adaptée le risque d'apparition de la toxémie gravidique. L'invention concerne en particulier une méthode permettant de détecter l'apparition de la toxémie gravidique chez un mammifère gravide. Cette méthode consiste à mesurer la concentration d'angiopoïétine 2 dans un liquide organique, à comparer la concentration d'angiopoïétine 2 obtenue à l'étape précédente à un niveau normal, et à déterminer la présence ou l'absence de risque d'apparition de la toxémie gravidique en fonction des résultats de cette comparaison. Pendant l'étape de comparaison, on considère qu'il existe un risque d'apparition de la toxémie gravidique pour la patiente si la concentration d'angiopoïétine 2 obtenue pendant l'étape de mesure est inférieure au niveau normal.

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