Method of expanding human hepatocytes in vivo

Details Method of expanding human hepatocytes in vivo Method of expanding human hepatocytes in vivo

G - Physics

01

N

G01N 33/50 (2006.01) C12N 5/071 (2010.01)

Patent

CA 2760608

Described herein is a method of expanding human hepatocytes in vivo using an immunodef?cient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises transplanting human hepatocytes into the immunodeficient and Fan-deficient mice, administering an IL-IR antagonist to the mouse and allowing the hepatocytes to expand. Alternatively, the method includes transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, wherein the mouse is further deficient for IL-IR and allowing the hepatocytes to expand. The method also allows serial transplantation of the human hepatocytes into secondary, tertiary, quaternary or additional mice.

L'invention porte sur un procédé d'expansion d'hépatocytes humains in vivo à l'aide d'une souris immunodéficiente qui est davantage déficiente en fumarylacétoacétate hydrolase (Fah). Le procédé comprend la transplantation d'hépatocytes humains dans les souris immunodéficientes et déficientes en Fan, l'administration d'un antagoniste de IL-IR à la souris et l'autorisation de l'expansion des hépatocytes. En variante, le procédé comprend la transplantation d'hépatocytes humains dans les souris immunodéficientes et déficientes en Fah, la souris étant en outre déficiente pour IL-IR, et l'autorisation de l'expansion des hépatocytes. Le procédé permet également une transplantation en série des hépatocytes humains dans des souris secondaires, tertiaires, quaternaires ou supplémentaires.

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