A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) C12N 5/078 (2010.01) A61K 41/00 (2006.01) C12N 13/00 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2367357
The present invention provides a method of expressing an antigenic molecule or a part thereof on the surface of an antigen-presenting cell, said method comprising introducing a molecule into the cell cytosol by photochemical internalisation, wherein said molecule, or a part thereof, is subsequently presented on the surface of said cell. Methods of vaccination comprising this method, together with compositions comprising said cells and uses involving said cells expressing antigenic molecules are also provided.
La présente invention concerne une technique permettant l'expression d'une molécule antigénique ou une partie de celle-ci sur la surface d'une cellule présentant un antigène, ladite technique comprenant l'introduction d'une molécule dans le cytosol cellulaire par internalisation photochimique. Cette molécule, ou une partie de celle-ci est subséquemment présenté sur la surface de ladite cellule. Cette invention concerne aussi des techniques de vaccination comprenant cette technique, ainsi que des compositions comprenant ces cellules et des utilisations mettant en oeuvre ces cellules exprimant des molécules antigéniques.
Berg Kristian
Hogset Anders
Prasmickaite Lina
Tjelle Torunn E.
Fetherstonhaugh & Co.
Photocure Asa
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