Method of forming a tablet

Details Method of forming a tablet Method of forming a tablet

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2671420

A method of forming a tablet includes the steps of pre-blending an active pharmaceutical ingredient susceptible to tackiness and a blending additive with a first mixing effort to form a pre-blend mixture, wherein the first mixing effort and a second mixing effort, resulting from mixing at least one excipient with the pre-blend mixture, form a blend suitable for direct compression and compressing the blend to form the tablet. One way of achieving the first mixing effort is to pre-blend for an extended period of time. The method allows for directly compressing the blend without the need for a granulation step or roller compression. One such active pharmaceutical ingredient susceptible to tackiness is ibuprofen.

Le procédé de formation d'un comprimé selon l'invention comprend les étapes de pré-mélange d'un ingrédient pharmaceutique actif susceptible d'adhésivité et d'un additif de mélange, avec un premier effort de mélange pour former un pré-mélange, le premier effort de mélange et un deuxième effort de mélange, résultant du mélange d'au moins un excipient avec le pré-mélange, formant un mélange approprié pour la compression directe, et la compression du mélange pour former le comprimé. Il est possible d'obtenir le premier effort de mélange en pré-mélangeant pendant une période prolongée. Le procédé permet la compression directe du mélange sans nécessiter une étape de granulation ou une compression au rouleau. Un tel ingrédient actif pharmaceutique susceptible d'adhésivité est l'ibuprofène.

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