Method of forming micropores in skin

Details Method of forming micropores in skin Method of forming micropores in skin

A - Human Necessities

61

N

A61N 7/00 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2389626

A method of forming pores (600) in the stratum corneum (210) includes applying an aqueous material (123) to a surface area of the stratum corneum followed by the application of sonic and/or ultrasonic radiation (112) to said aqueous material wherein said sonic and/or ultrasonic radiation has a frequency in the range of 10KHz and 5 MHz and is applied at an intensity, for a period of time and at a distance from said surface area of the stratum corneum effective to generate cavitation bubbles (500) on said surface area of the stratum corneum, wherein said cavitation bubbles collapse and transfer their energy into the stratum corneum causing the formation of pores. Large size molecules ( > 500Da) dissolved in the aqueous material can transfer through these pores and across the stratum corneum and reach the blood vessels at flow rates suitable for therapeutic applications.

Une méthode de formation de pores (600) dans la stratum corneum (210) consiste à appliquer une matière aqueuse (123) sur une zone de surface de la stratum corneum puis à appliquer un rayonnement sonore et/ou ultrasonore (112) à ladite matière aqueuse, dans laquelle ledit rayonnement sonore et/ou ultrasonore a une fréquence dans la gamme de 10 KHz et 5 MHz et est appliqué à une intensité, pendant une durée, et à une distance de ladite zone de surface de la stratum corneum efficace pour produire des bulles de cavitation (500) sur ladite zone de surface de la stratum cornenum, dans laquelle lesdites bulles de cavitation s'écrasent et transfèrent leur énergie dans la stratum corneum engendrant la formation de pores. Des molécules de grande taille ( > 500Da) dissoutes dans la matière aqueuse peuvent être transférées à travers ces pores et à travers la stratum corneum, puis atteindre les vaisseaux sanguins à des débits convenant à des applications thérapeutiques.

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