Method of forming oligonucleotides

Details Method of forming oligonucleotides Method of forming oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01)

Patent

CA 2160016

A method of forming an oligonucleotide is disclosed, the method including the steps of disposing in solution at least two oligonucleotides in aqueous solution wherein one of the oligonucleotides includes an .alpha.-haloacyl group and the other of the nucleotides includes a phosphothioate group and covalently binding the oligonucleotides together through the .alpha.-haloacyl group and the phosphothioate group spontaneously forming a thiophosphorylacetylamino group therebetween.

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