Method of generating islet beta-cells from exocrine...

Details Method of generating islet beta-cells from exocrine... Method of generating islet beta-cells from exocrine...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/39 (2006.01) A61K 38/18 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2527626

The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF receptor and the GP130 receptor, such as EGF and LIF. Insulin secreting cells, obtainable by this method, provide a means for the treatment of diabetes by islet transplantation.

L'invention porte sur un procédé <i>in vitro</i> permettant d'induire la différenciation de cellules bêta de mammifères dans des cellules exocrines dédifférenciées du pancréas, dans un milieu comprenant des ligands du récepteur EGF et du récepteur GP130, tels que le EGF et le LIF. Les cellules sécrétrices d'insuline obtenues par ce procédé permettent de traiter le diabète par transplantation des îlots de Langerhans.

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