C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2725169
The present invention describes methods of generating single VL domain antibodies, including chimeric single chain antibodies that comprise of a variable region of a human immunoglobulin .kappa. or .lambda. light chain and a non-human constant region. The non-human constant region is devoid of a first constant domain CH1, and the variable region is devoid of a heavy chain variable domain.
La présente invention concerne des procédés de génération danticorps à domaine VL unique, comprenant des anticorps à chaîne unique chimériques qui se composent dune région variable dune chaîne légère ? ou ? dimmunoglobuline humaine et dune région constante non humaine. La région constante non humaine est dépourvue dun premier domaine constant CH1, et la région variable est dépourvue dun domaine variable de chaîne lourde.
Green Larry
Shizuya Hiroaki
Aliva Biopharmaceuticals Inc.
Borden Ladner Gervais Llp
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