Method of grinding pharmaceutical substances

Details Method of grinding pharmaceutical substances Method of grinding pharmaceutical substances

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/57 (2006.01)

Patent

CA 2190966

A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.

Un procédé de préparation de particules sub-microniques d'un agent thérapeutique ou diagnostique consiste à broyer l'agent en présence de milieu de broyage présentant une grosseur particulaire moyenne inférieure à environ 75 microns. Dans un mode de réalisation préféré, le milieu de broyage est une résine polymère. Le procédé permet d'obtenir des particules extrêmement fines, par exemple d'une grosseur inférieure à 100 nanomètres, exemptes de contaminations non acceptables.

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