C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/02 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/00 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2497287
Disclosed are methods for making immune system molecules, particularly humanized antibodies and fragments thereof. A typical method optimizes similarity between individual antibody framework regions to help identify human framework regions suitable for making the molecules. Comparisons between larger antibody frameworks, hypervariable domains or both is avoided. Also disclosed are antibodies that have been humanized by the method. The invention has a wide spectrum of applications including use in the production of humanized monoclonal antibodies with suitable binding affinity and minimized human immunogenicity.
L'invention concerne des procédés permettant de fabriquer des molécules du système immunitaire, en particulier des anticorps humanisés et des fragments de ces derniers. Un procédé général permet d'optimiser la similarité entre des régions de structure d'anticorps individuel pour aider à identifier des régions de structure humaine permettant de fabriquer lesdites molécules. L'invention permet d'éviter de comparer des structures d'anticorps et/ou des domaines hypervariables plus importants. L'invention concerne également des anticorps qui ont été humanisés selon ledit procédé. L'invention présente un large champ d'applications, notamment l'utilisation dans la production d'anticorps monoclonaux humanisés présentant une affinité de liaison appropriée et une immunogénicité humaine réduite au minimum.
Mosquera Luis A.
Stinson Jeffrey R.
Wong Hing C.
Ridout & Maybee Llp
Sunol Molecular Corporation
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