C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2267285
The present invention relates to materials and methods for identifying animals that are resistant or susceptible to diseases associated with intracellular parasites such as brucellosis, tuberculosis, paratuberculosis and salmonellosis. More particularly, the present invention relates to the identification of a gene, called NRAMP1, which is associated with the susceptibility or resistance of an animal, such as an artiodactyla to diseases such as brucellosis, tuberculosis, paratuberculosis and salmonellosis. Still more particularly, the present invention relates to the identification of specific sequences of bovine NRAMP1 which associate with resistance or susceptibility to ruminant brucellosis, tuberculosis, paratuberculosis and salmonellosis, and to the method of identifying said sequences to identify animals who are susceptible or resistant to disease.
L'invention concerne des matériels et des méthodes pour l'identification d'animaux qui sont résistants ou sensibles à des maladies associées à des parasites intracellulaires telles que la mélitococcie, la tuberculose, la maladie de Johne et la salmonellose. Elle se rapporte notamment à l'identification d'un gène appelé NRAMP1, qui est associé à la sensibilité ou à la résistance d'un animal, tels que les Artiodactyles, à des maladies, telles que la mélitococcie, la tuberculose, la maladie de Johne et la salmonellose. Elle porte, encore plus spécifiquement, à l'identification de séquences spécifiques de NRAMP1 bovin qui sont associées à la résistance ou à la sensibilité à la mélitococcie, la tuberculose, la maladie de Johne et la salmonellose, et sur des méthodes d'identification desdites séquences pour l'identification d'animaux sensibles ou résistants à une certaine maladie.
Adams L. Garry
Davis Donald S.
Feng Jianwei
Gros Philippe
Schurr Erwin
Borden Ladner Gervais Llp
The Texas A. & M. University System
University Mcgill
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