Method of identifying agents that alter the activity of the...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/10 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) C07K 14/575 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2407834

A method for identifying agents that alter the activity of the promoter region of CRF~2.alpha. receptor is disclosed. In one embodiment, the method comprises the steps of (a) obtaining a cell line or organism, wherein the cell line or organism comprises a nucleic acid sequence encoding a promoter sequence of a heterologous CRF~2.alpha. receptor operably attached to a reporter gene and (b) introducing a test agent into the cell or transgenic animal and evaluating the expression of the reporter gene product compared to a control cell line or transgenic animal wherein the agent has not been introduced into the cell line or transgenic animal.

L'invention concerne un procédé permettant d'identifier des agents qui affectent l'activité de la région promotrice du récepteur de CFR2 alpha . Dans un mode de réalisation, le procédé comprend comme étapes : (a) obtenir une lignée ou un organisme cellulaire comprenant un acide nucléique codant une séquence promotrice d'un récepteur de CRF2 alpha hétérologue fixé de manière fonctionnelle à un gène rapporteur et (b) introduire un agent d'essai dans la cellule ou l'animal transgénique et évaluer l'expression du gène rapporteur obtenu comparativement à une ligne cellulaire ou à un animal transgénique de contrôle, dans laquelle/lequel l'agent n'a pas été introduit.

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