Method of identifying and/or isolating stem cells

Details Method of identifying and/or isolating stem cells Method of identifying and/or isolating stem cells

G - Physics

01

N

G01N 33/48 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2410515

The present invention includes methods of identifying and/or isolating stem cells based on expression of BCRP. The present invention also describes methods of obtaining and/or using cell populations enriched for stem cells. In addition, methods are provided for diagnosing and/or prognosing leukemia, particularly human acute myelogenous leukemia (AML), through assaying for BCRP expression in leukemic cells.

L'invention concerne des procédés d'identification et/ou d'isolement de cellules souches basés sur l'expression du gène BCRP. Elle concerne aussi des procédés permettant d'obtenir et/ou d'utiliser des populations cellulaires enrichies pour des cellules souches. Elle concerne enfin des procédés de diagnostic et/ou de pronostic de leucémie, notamment la leucémie myéloïde humaine aiguë (AML) au travers de tests d'expression du gène BCRP dans des cellules leucémiques.

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