Method of identifying individuals at risk of thiopurine drug...

Details Method of identifying individuals at risk of thiopurine drug... Method of identifying individuals at risk of thiopurine drug...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2695897

The invention relates to methods and kits for identifying individuals at risk of thiopurine drug intolerance based on detecting the presence of mutations in the TPMT gene promoter associated with thiopurine drug resistance or intolerance.

L'invention concerne des méthodes et des kits permettant d'identifier des individus présentant un risque d'intolérance aux médicaments à base de thiopurines, ces méthodes consistant à détecter la présence de mutations dans le promoteur du gène TPMT associé à l'intolérance ou à la résistance aux médicaments à base de thiopurines.

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