Method of identifying inhibitors of cdc25

Details Method of identifying inhibitors of cdc25 Method of identifying inhibitors of cdc25

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 38/43 (2006.01) A61P 35/00 (2006.01) C07K 5/10 (2006.01) C07K 5/107 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2383603

The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.

La présente invention concerne des polypeptides comprenant le domaine de liaison aux ligands de Cdc25, les formes cristallines de ces polypeptides et l'utilisation de ces formes cristallines pour déterminer la structure tridimensionnelle du domaine catalytique de Cdc25. L'invention concerne également l'utilisation de la structure tridimensionnelle du domaine catalytique de Cdc25 dans des méthodes de conception et/ou d'identification d'inhibiteurs potentiels de l'activité de Cdc25, par exemple des composés inhibant la liaison d'un substrat natif au domaine catalytique de Cdc25.

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