Method of identifying inhibitors of tie-2

Details Method of identifying inhibitors of tie-2 Method of identifying inhibitors of tie-2

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) A61P 35/00 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2404532

The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The invention also relates to the use of the three dimensional structure of the Tie-2 catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Tie-2 activity, for example, compounds which inhibit the binding of a native substrate to the Tie-2 catalytic domain.

La présente invention concerne des polypeptides contenant le domaine de liaison du ligand de Tie-2, les formes cristallines de ces polypeptides ainsi que l'utilisation de ces formes cristallines pour déterminer la structure tridimensionnelle du domaine catalytique de Tie-2. En outre, cette invention concerne l'utilisation de cette structure tridimensionnelle du domaine catalytique de Tie-2, à la fois seule ou associée à des inhibiteurs, dans des procédés de désignation et/ou d'identification des inhibiteurs potentiels de l'activité de Tie-2, par exemple, des composés qui inhibent la liaison d'un substrat natif au domaine catalytique de Tie-2.

Affiliated with

Also associated with

Rating

Method of identifying inhibitors of tie-2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying inhibitors of tie-2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying inhibitors of tie-2 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1568022