C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 47/48 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01) C07K 16/42 (2006.01) C12N 5/10 (2006.01) C40B 30/04 (2006.01) C40B 40/10 (2006.01)
Patent
CA 2624081
The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell -mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells.
L'invention porte sur la découverte d'anticorps se fixant sur de nouveaux épitopes présents sur les immunoglobulines membranaires et se liant auxdits épitopes à la surface des cellules B et des cellules du plasma. En outre, lesdits anticorps peuvent médier l'ADCC et servir à épuiser les cellules B et les cellules du plasma exprimant le nouvel épitope de l'invention. Lesdits anticorps peuvent servir à traiter les maladies médiées par les cellules B et les maladies causées par l'expansion monoclonale des cellules B. L'invention porte donc par conséquent sur des compositions et méthodes de prévention, gestion, traitement, ou amélioration de maladies médiées par les cellules B et de maladies causées par l'expansion monoclonale des cellules B.
Chowdhury Partha S.
Kiener Peter
Wu Herren
Young James F.
Medimmune Inc.
Smart & Biggar
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