Method of identifying molecules that regulate fgf activity

Details Method of identifying molecules that regulate fgf activity Method of identifying molecules that regulate fgf activity

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2215391

Disclosed are fibroblast growth factor (FGF) binding and FGF receptor activation, and a method of identifying small molecular weight compounds that interact with FGF to modulate its activity such as, e.g., activators and inhibitors. Illustrative small oligosaccharides, namely di- and tri- saccharides, are shown to be effective modulators of FGF binding and FGF receptor activation.

L'invention porte sur l'activation des fonctions de liaison et de réception du facteur de croissance fibroblaste (FGF) et sur un procédé d'identification de composés de faible poids moléculaire, activateurs ou inhibiteurs, qui interagissent avec le FGF pour en réguler l'activité. A titre d'exemple, de petits oligosaccharides tels que les di- et tri-saccharides se sont avérés être d'efficaces régulateurs des fonctions de liaison et de réception du FGF.

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