Method of identifying risk for thyroid disorder

Details Method of identifying risk for thyroid disorder Method of identifying risk for thyroid disorder

Category

G - Physics

Subcategory

01

Subsubcategory

N

IPC codes

G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/74 (2006.01)

Type

Patent

Patent number

CA 2678199

Description

A method for identifying a patient that is at risk for developing a thyroid disorder that occurs subsequent to treatment with a regimen that depletes lymphocytes, comprising determining whether antibodies directed against thyroid peroxidase or thyroid microsomes are present in the patient, wherein if the antibodies are present in the patient then the patient is at increased risk for developing a thyroid disorder. A particular embodiment is a method for identifying a patient with multiple sclerosis that is at risk for developing a thyroid disorder that occurs subsequent to treatment with a regimen that depletes CD52-positive cells, comprising determining whether antibodies directed against thyroid peroxidase or thyroid microsomes are present in the patient, wherein if the antibodies are present in the patient then the patient is at risk for developing the thyroid disorder.

L'invention a pour objet une méthode pour identifier un patient présentant un risque de développer un trouble thyroïdien survenant suite à un traitement mettant en AEuvre un protocole qui détruit les lymphocytes, comprenant le fait de déterminer si les anticorps dirigés contre la thyroperoxydase ou contre les microsomes thyroïdiens sont présents chez le patient ; si on rencontre ces anticorps chez le patient, le patient présente alors un risque accru de développer un trouble thyroïdien. Un mode de réalisation particulier est une méthode pour identifier un patient atteint de sclérose en plaques présentant un risque de développer un trouble thyroïdien survenant suite à un traitement mettant en AEuvre un protocole qui détruit les cellules positives au CD52, comprenant le fait de déterminer si les anticorps dirigés contre la thyroperoxydase ou contre les microsomes thyroïdiens sont présents chez le patient ; si on rencontre ces anticorps chez le patient, ce dernier présente alors un risque de développer un trouble thyroïdien.

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