Method of immunologically assaying human...

Details Method of immunologically assaying human... Method of immunologically assaying human...

C - Chemistry, Metallurgy

12

N

167/139, 195/35,

C12N 11/18 (2006.01) A61K 39/395 (2006.01) C12N 9/74 (2006.01) G01N 33/543 (2006.01) G01N 33/573 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2014016

Abstract of the Disclosure A method of immunologically assaying a human thrombin-antithrombin III complex in a human assay sample by using a first antibody composed of an insoluble carrier and an anti-human thrombin polyclonal antibody fixed to the insoluble carrier and a second antibody composed of an anti-human antithrombin III antibody and a labelling substance bound thereto; wherein (1) the anti-human thrombin polyclonal antibody has (a) a dissociation constant with respect to human thrombin of 2.5 x 10-9M to 3.5 x 10-9M, (b) a dissociation constant with respect to human prothrombin of 4.5 x 10-7M to 5.5 x 10-7M, (c) a dissociation constant with respect to the human thrombin-antithrombin III complex of 0.5 x 10-9M to 1.5 x 10-9M, and (d) a cross-reactivity with human prothrombin of not more than 0.05 %, and (2) the anti-human thrombin polyclonal antibody is bound to the insoluble carrier at a rate of 2 to 25 % based on the saturated amount of the polyclonal antibody bound to the insoluble carrier, and a kit therefor.

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