Method of improved diuresis in individuals with impaired...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/522 (2006.01) A61K 31/63 (2006.01) A61K 31/635 (2006.01) A61P 7/10 (2006.01)

Patent

CA 2522971

Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect.

L'invention concerne une composition pharmaceutique contenant une quantité thérapeutiquement efficace de KW-3902 ou bien un sel, un ester, un amide, un métabolite ou un précurseur de ceux-ci, ainsi qu'un diurétique ne modifiant pas l'adénosine. La présente invention porte également sur des procédés pour produire un effet diurétique chez un animal, ces procédés consistant à administrer une quantité thérapeutiquement efficace de KW-3902 ou bien un sel, un ester, un amide, un métabolite ou un précurseur de ceux-ci, en combinaison avec une seconde composition pharmaceutique apte à produire un effet diurétique.

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