Method of improving cell proliferation of pancreatic...

Details Method of improving cell proliferation of pancreatic... Method of improving cell proliferation of pancreatic...

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01)

Patent

CA 2637843

The invention relates to the discovery that the proliferation and survival of pancreatic progenitor cells can be enhanced by contacting the cells with, (1) a caspase inhibitor sufficient to reduce apoptosis in the pancreatic endocrine cells; and, (2) a growth factor in an amount sufficient to increase the level of activated Akt in the pancreatic endocrine cells.

L'invention concerne un procédé permettant d'améliorer la prolifération et la survie des cellules progénitrices pancréatiques, lequel procédé consiste à mettre les cellules en contact avec (1) un inhibiteur de caspase suffisant pour réduire l'apoptose dans les cellules endocrines pancréatiques; et avec (2) un facteur de croissance, dans une quantité suffisante pour augmenter le niveau d'Akt activé dans les cellules endocrines pancréatiques.

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