Method of improving renal function

Details Method of improving renal function Method of improving renal function

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/549 (2006.01) A61K 35/12 (2006.01) A61K 47/34 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2661409

A method of improving renal function in a mammal suffering from, or at risk of developing, at least partial renal failure or renal dysfunction, includes administering to renal tissue of the mammal, a combination comprising a non-viral vector comprising a non-viral particulate carrier which carries a therapeutically effective amount of genetic material capable of expressing a renal function-enhancing Osteogenic Protein-1/Bone Morphogenic Protein-7 (OP-1/BMP-7) polypeptide in the renal tissue.

Méthode d'amélioration de la fonction rénale chez un mammifère souffrant ou risquant de souffrir d'une défaillance rénale au moins partielle ou d'un dysfonctionnement rénal. Cette méthode consiste à administrer au tissu rénal de ce mammifère une combinaison comprenant un vecteur non viral constitué d'un vecteur particulaire non viral portant une dose thérapeutiquement efficace d'un matériau génétique capable d'exprimer un polypeptide de protéine ostéogénique 1/protéine morphogénique osseuse 7 (OP-1/BMP-7) dans le tissu rénal.

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