C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01)
Patent
CA 2536588
A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1-/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
L'invention concerne un procédé pour différentier des cellules souches embryonnaires dans des cellules neuronales et motrices. Dans un mode de réalisation, l'invention comprend la culture d'une population de cellules comprenant une majorité de cellules caractérisées par une morphologie de rosette précoce et sont représentées par Sox1?-¿/Pax6?+¿ en présence de FGF2, FGF4, FGF8, FGF9, ou RA, les cellules étant caractérisées par une morphologie de rosette précoce et représentées par Pax6?+¿/Sox1?+¿.
Duncan Ian David
Li Xue-Jun
Thomson James A.
Zhang Su-Chun
Bcf Llp
Wisconsin Alumni Research Foundation
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