Method of inactivating microorganisms

Details Method of inactivating microorganisms Method of inactivating microorganisms

C - Chemistry, Metallurgy

12

N

C12N 7/06 (2006.01) A61K 39/135 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2394946

This invention provides methods of inactivating a microorganism and preparing a vaccine including the step of applying to said microorganism a cross-linking agent simultaneously with a separate inactivant. This invention further relates to vaccines prepared by such methods and a kit including such inactivated microorganism. The cross-linking agent is typically formaldehyde (FA) and the inactivant typically binary ethyleneimine (BEI).

La présente invention concerne des méthodes permettant d'inactiver des micro-organismes et de préparer un vaccin, consistant à appliquer auxdits micro-organismes un agent de réticulation en même temps qu'un agent inactivant séparé. L'invention concerne en outre des vaccins préparés selon ces méthodes et des kits comprenant ces micro-organismes inactivés. L'agent de réticulation est généralement un formaldéhyde (FA), l'agent inactivant étant généralement l'éthylèneimine binaire (BEI).

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