A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
167/114, 167/139
A61L 2/04 (2006.01) A61K 35/16 (2006.01) A61L 2/00 (2006.01)
Patent
CA 1239583
ABSTRACT OF THE DISCLOSURE: A method of inactivating viruses in blood products is described, wherein the blood products are heat-treated in a humid or in a solid state in the presence of inorganic or organic hydroxyl group-containing compounds having an H+- dissociation constant of < 10-11 in a concentration of more than 0.05 (5 % by weight) and less than 0.70 (70 % by weight). The hydroxyl group-containing compounds may be water, methanol, or ethanol. The temperature may amount up to 121°C, the heat treatment may last from 1 s to 100 h. The inactivation method may be applied for producing blood products selected from enzymes, proenzymes including coagulation factors, enzyme inhibitors, immunoglobulins, albumin, plasminogen, fibrinogen, fibronectin or plasma, the inactivation destroying any reproducible filterable pathogens that might be present.
475883
Dorner Friedrich
Eibl Johann
Elsinger Friedrich
Frechinger Wolfgang
Linnau Yendra
Baxter Aktiengesellschaft
Fetherstonhaugh & Co.
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