Method of increasing the presence of glutathione in cells

Details Method of increasing the presence of glutathione in cells Method of increasing the presence of glutathione in cells

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/198 (2006.01) A61P 1/16 (2006.01) A61P 39/06 (2006.01) A61K 35/78 (2000.01)

Patent

CA 2459547

There is provided a method of increasing the presence of glutathione in cells including treating or preventing of impaired liver function by administering to a mammal in the need thereof a dietetic or pharmaceutical composition and to a corresponding dietetic or pharmaceutical composition. Said composition contains at least one of each of the following components a) a precursor of glutathione which is selected from the group consisting of cysteine and functional equivalents containing said amino acid; b) an enhancer of the glutathione biosynthesis; and c) a third component which is either selected from lignans or which is a combination c1) of an enhancer of glutathione regeneration and c2) of an enhancer of the glutathione-mediated conjugation.

La présente invention concerne une méthode permettant d'augmenter la présence de glutathione dans des cellules. Ladite méthode consiste à traiter ou à prévenir la fonction hépatique altérée par administration, à un mammifère le nécessitant, d'une composition diététique ou pharmaceutique. Ladite composition contient au moins un des constituants suivants a) un précurseur de glutathione qui est sélectionné dans le groupe constitué de cystéine et d'équivalents fonctionnels contenant ledit acide aminé; b) un amplificateur de la biosynthèse de glutathione; et c) un troisième constituant qui est sélectionné dans des lignanes ou qui est une combinaison, c1) d'un amplificateur de régénération de glutathione et c2) d'un amplificateur de la conjugaison induite par la glutathione.

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