Method of inducing and maintaining neuronal cells

Details Method of inducing and maintaining neuronal cells Method of inducing and maintaining neuronal cells

C - Chemistry, Metallurgy

12

N

C12N 5/079 (2010.01) A61K 31/17 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 38/57 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C07K 14/71 (2006.01) C12Q 1/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2174098

The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The subject method stems from the unexpected finding that, contrary to traditional unterstanding of neural induction, the default fate of ectodermal tissue is neuronal rather than mesodermal and/or epidermal. In particular, it has been discovered that preventing or antagonizing a signaling pathway in a cell for a growth factor of the TGF-.beta. family can result in neuronal differentiation of that cell.

L'invention concerne un procédé permettant d'induire une différentiation neuronale et d'empêcher la mort ou la dégénérescence de cellules neuronales tant in vitro qu'in vivo. Le procédé de l'invention se base sur la découverte surprenante que, contrairement à la compréhension traditionnelle que l'on a eue jusqu'à présent de l'induction neuronale, la fatalité d'un défaut des tissus ectodermiques est de type neuronal plutôt que de type mésodermique et/ou épidermique. En particulier on a découvert que le fait d'empêcher ou neutraliser un chemin de signalisation dans une cellule pour un facteur de croissance de la famille TGF-.beta. peut avoir comme résultat la différenciation neuronale de cette cellule.

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