A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/277 (2006.01) A61K 31/44 (2006.01) A61K 31/502 (2006.01) A61K 31/519 (2006.01) A61K 38/24 (2006.01) A61K 45/06 (2006.01) A61P 15/08 (2006.01)
Patent
CA 2469939
The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
L'invention concerne des méthodes permettant d'induire l'ovulation chez un hôte femelle. Ces méthodes consistent à administrer à ce dernier un modulateur du taux d'un adénosine monophosphate cyclique (cAMP) non polypeptidique. Dans un autre aspect, l'invention concerne l'administration spécifique de l'inhibiteur de la phosphodiestérase avant la phase lutéinique du cycle ovulatoire de l'hôte. Parmi les modulateurs préférés du taux de cAMP non polypeptidique, on trouve les inhibiteurs de la phosphodiestérase, notamment les inhibiteurs des isoformes 4 de la phosphodiestérase.
Eshkol Aliza
Macnamee Michael C.
Mckenna Sean
Palmer Stephen
Tepper Mark
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Merck Serono Sa
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