Method of inhibiting a chaperone protein

Details Method of inhibiting a chaperone protein Method of inhibiting a chaperone protein

A - Human Necessities

61

K

A61K 31/37 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2367108

The present invention provides a method of inhibiting binding of a chaperone protein with its client protein or client polypeptide. This method comprises contacting coumarin or a coumarin derivative with a chaperone protein, such that the coumarin or the coumarin derivative binds the chaperone protein, which inhibits the chaperon protein from binding its client protein or client polypeptide.

La présente invention concerne une méthode utilisée pour empêcher une protéine chaperonne de se fixer à sa protéine client ou à son polypeptide client. La méthode implique de mettre en relation un coumarinique ou un dérivé de coumarinique avec une protéine chaperonne, de telle sorte que le coumarinique ou le dérivé de coumarinique se fixe sur la protéine chaperonne, empêchant ainsi la protéine chaperonne de se fixer sur sa protéine client ou son polypeptide client.

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