Method of inhibiting amyloid protein aggregation and imaging...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/44 (2006.01) A61K 31/4035 (2006.01) A61K 49/06 (2006.01) A61K 51/04 (2006.01) A61P 43/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2373394

The present invention provides a method of treating Alzheimer's disease using a novel compound of formula (I), wherein X is phenyl or substituted phenyl; Y is phenyl, substituted phenyl, pyridyl, or substituted pyridyl. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of formula (I) and a method of imaging amyloid deposits using isoindoline derivatives.

La présente invention concerne un procédé de traitement de la maladie d'Alzheimer au moyen d'un nouveau composé correspondant à la formule (I), dans laquelle X représente phényle ou phényle substitué; Y représente phényle, phényle substitué, pyridyle ou pyridyle substitué. L'invention concerne également un procédé d'inhibition de l'agrégation de protéines amyloïdes au moyen d'un composé correspondant à la formule (I) et un procédé d'imagerie de dépôts amyloïdes au moyen de dérivés d'isoindoline.

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