C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/58 (2006.01) A61K 31/196 (2006.01) A61K 31/245 (2006.01) A61K 49/00 (2006.01) A61P 25/28 (2006.01) C07C 229/56 (2006.01) C07C 229/60 (2006.01) C07C 229/64 (2006.01)
Patent
CA 2405611
The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R1 and R2 include alkyl and phenylalkyl; R3 is hydrogen or alkyl; and R4 and R5 include alkyl, alkoxy, carboxyl, alkoxycarbonyl, and nitro. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using compounds of Formula (I).
La présente invention concerne des composés correspondant à la formule (I) ainsi qu'un procédé pour traiter la maladie d'Alzheimer faisant appel à un tel composé. Dans ladite formule (I), R?1¿ et R?2¿ représentent alkyle et phénylalkyle; R?3¿ représente hydrogène ou alkyle; et R?4¿ et R?5¿ représentent alkyle, alcoxy, carboxyle, alcoxycarbonyle et nitro. L'invention concerne également un procédé d'inhibition de l'agrégation de protéines amyloïdes faisant appel à un composé de ladite formule (I), ainsi qu'un procédé d'imagerie de dépôts amyloïdes faisant également appel à un composé de ladite formule (I).
Barta Nancy Sue
Bigge Christopher Franklin
Sim & Mcburney
Warner-Lambert Company
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