Method of inhibiting biomaterial-induced procoagulant...

Details Method of inhibiting biomaterial-induced procoagulant... Method of inhibiting biomaterial-induced procoagulant...

A - Human Necessities

61

K

A61K 47/42 (2006.01) A61M 1/14 (2006.01) A61M 1/34 (2006.01) A61K 35/14 (2006.01)

Patent

CA 2738930

Methods for reducing or eliminating biomaterial-induced procoagulant activity in blood subjected to extracorporeal treatment that exposes the blood to the biomaterial are disclosed. The methods involve treatment of the blood, or the extracorporeal biomaterial, or both, with a complement inhibitor to inhibit C5a/C5aR-mediated tissue factor formation in the blood.

La présente invention concerne des procédés destinés à réduire ou à éliminer une activité procoagulante induite par des biomatériaux dans le sang soumis à un traitement extracorporel qui expose le sang au biomatériau. Les procédés comprennent le traitement du sang, ou du biomatériau extracorporel, ou des deux, par un inhibiteur du complément afin dinhiber la formation de facteurs tissulaires induits par les C5a/C5aR dans le sang.

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