Method of inhibiting cathepsin k

Details Method of inhibiting cathepsin k Method of inhibiting cathepsin k

C - Chemistry, Metallurgy

12

N

C12N 9/48 (2006.01) C07K 14/81 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2301201

A novel procathepsin K crystalline structure is identified. Also disclosed are methods of identifying inhibitors of cathepsin K and methods of designing inhibitors of cathepsin K using structural and physical data based on the crystallographic structure of procathepsin K.

On a identifié une nouvelle structure cristalline de cathepsine K. La présente invention concerne également des procédés qui permettent d'identifier des inhibiteurs de cathepsine K et des procédés qui permettent de mettre au point des inhibiteurs de cathepsine K à l'aide de données structurelles et physiques fondées sur la structure cristallographique de la procathepsine K.

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