Method of inhibiting cathepsin k

Details Method of inhibiting cathepsin k Method of inhibiting cathepsin k

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 38/05 (2006.01) C07C 243/34 (2006.01) C07C 311/16 (2006.01) C07C 311/29 (2006.01) C07D 207/273 (2006.01) C07D 211/72 (2006.01) C07D 211/96 (2006.01) C07D 213/30 (2006.01) C07D 215/36 (2006.01) C07D 241/24 (2006.01) C07D 249/10 (2006.01) C07D 271/10 (2006.01) C07D 277/56 (2006.01) C07D 285/12 (2006.01) C07D 285/125 (2006.01) C07D 295/155 (2006.01) C07D 295/215 (2006.01) C07D 307/91 (2006.01) C07D 333

Patent

CA 2209109

A novel cathepsin K crystalline structure is identified. Also disclosed are methods of identifying inhibitors of this protease and methods of inhibiting cathepsin K using inhibitors with certain structural, physical and spatial characteristics.

Une nouvelle structure cristalline de cathepsine K a été identifiée. L'invention décrit également des procédés d'identification d'inhibiteurs de cette protéase ainsi que des procédés d'inhibition de la cathepsine K à l'aide d'inhibiteurs présentant certaines caractéristiques structurelles, physiques et spatiales.

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