Method of inhibiting conditions associated with bradykinin

Details Method of inhibiting conditions associated with bradykinin Method of inhibiting conditions associated with bradykinin

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2203914

A method of inhibiting a physiological condition associated with an excess of bradykinin comprising administering to a human in need thereof an effective amount of a compound having formula (I) wherein R1 and R3 are independently hydrogen, -CH3, (a) or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

Procédé permettant de traiter des troubles physiologiques dus à un excédent de bradykinine. Il consiste à administrer à un patient une quantité efficace d'un composé de formule (I) où R?1¿ et R?3¿ représentent indépendemment hydrogène, -CH¿3?, (a) ou (b), où Ar représente phényle éventuellement substitué; R?2¿ est choisi dans le groupe consistant en pyrrolidine, hexaméthylèneimino et pipéridino. L'invention concerne ce composé ou un de ses sels de solvate pharmacologiquement acceptables.

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