Method of inhibiting demineralization of bone

A - Human Necessities – 61 – K

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A61K 31/475 (2006.01) A61K 31/445 (2006.01) A61K 31/48 (2006.01)

Patent

CA 2042960

X-7020A Abstract A method of inhibiting bone demineralization comprising administration of an effective amount of a compound having the formula Image where X is CH or N; Y is O or S; R1 is 2-propenyl, C1-C3 alkyl. benzyl or substituted benzyl where the substitutents are one or two of the same or different and are selected from methyl, ethyl, methoxy, ethoxy, hydroxy, chloro, bromo, or fluoro; R2 is C2-C3 alkyl, allyl or cyclopropylmethyl; R3 and R4 are both hydrogen or combine to form a carbon-carbon bond; and pharmaceutically acceptable acid addition salts thereof to a mammal requiring bone demineralization inhibition.

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