A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/65 (2006.01)
Patent
CA 2320260
The invention is a method of inhibiting the activity of membrane-type matrix metalloproteinase (MT-MMP) in biological systems. Accordingly, the invention permits the treatment of medical conditions in mammals that are characterized by MT-MMP activity, and especially those conditions characterized by excessive MT-MMP activity. The method employs a tetracycline compound, preferably a non- antimicrobial tetracycline, and more preferably 6-demethyl-6-deoxy-4- de(dimethylamino)tetracycline (CMT-3) or 6-.alpha.-deoxy-5-hydroxy-4- de(dimethylamino)tetracycline (CMT-8) to inhibit the MT-MMP activity.
L'invention concerne une méthode d'inhibition de l'activité de métalloprotéases matricielles de type membranaires (MT-MMP) dans des systèmes biologiques. Ainsi, l'invention permet de traiter chez des mammaliens des affections médicales se caractérisant par une activité de MT-MMP, ces affections en particulier se caractérisant par une activité de MT-MMP excessive. La méthode consiste à faire appel à un composé de tétracycline, de préférence une tétracycline non antimicrobienne et idéalement une 6-déméthyl-6-désoxy-4-dé(diméthylamino)tétracycline (CMT-3) ou une 6-.alpha.-désoxy-5-hydroxy-4-dé(diméthylamino)tétracycline (CMT-8), pour inhiber l'activité de MT-MMP.
Golub Lorne M.
Lee Hsi-Ming
Salo Tuula
Sorsa Timo
Teronen Olli
Piasetzki & Nenniger Llp
The Research Foundation Of State University Of New York
LandOfFree
Method of inhibiting membrane-type matrix metalloproteinase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of inhibiting membrane-type matrix metalloproteinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inhibiting membrane-type matrix metalloproteinase will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1379542