A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/225 (2006.01) A61K 31/03 (2006.01) A61K 31/09 (2006.01) A61K 31/136 (2006.01) A61K 31/196 (2006.01) A61P 19/08 (2006.01)
Patent
CA 2647796
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteociastogenesis is administered to the patient. Pharmaceutical compositions which comprise TRANCE/RANK inhibitor in an amount effective to inhibit osteociastogenesis. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of a TRANCE/RANK inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems.
Greene Mark I.
Kinosaki Masahiko
Murali Ramachandran
Robic
The Trustees Of The University Of Pennsylvania
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