Method of inhibiting padgem-mediated interactions using an...

A - Human Necessities – 61 – K

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A61K 38/18 (2006.01) A61K 31/70 (2006.01) A61K 31/78 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2105997

2105997 9216612 PCTABS00016 The invention relates to a method of inhibiting (reducing or preventing) the interaction or adhesion of a PADGEM-bearing cell with a cell bearing a PADGEM ligand by contacting the PADGEM-bearing cell with an inhibitor comprising a 2,6-linked sialic acid component. By the method of the present invention, it is possible to inhibit the interaction of a PADGEM-bearing cell, such as a platelet or endothelial cell, with a cell bearing a PADGEM ligand, such as a white blood cell (leukocyte) by contacting the cell with an inhibitor comprising a 2,6-linked sialic acid residue. The invention further relates to inhibitors useful in the present method.

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