Method of inhibiting parasitic activity

Details Method of inhibiting parasitic activity Method of inhibiting parasitic activity

A - Human Necessities

61

K

A61K 31/20 (2006.01) A61K 31/19 (2006.01) A61K 31/22 (2006.01) A61K 31/23 (2006.01)

Patent

CA 2058868

METHOD OF INHIBITING PARASITIC ACTIVITY Abstract of the Disclosure A method of inhibiting parasitic activity is disclosed in which the biosynthesis of the glycosyl phosphatidyllnositol (GPI) anchor of said parasite is inhibited by incorporating into said GPI anchor an oxy- substituted fatty acid analog in place of myristate. The inhibitory compounds are C13 and C14 fatty acids or alkyl esters thereof in which a methylene group normally in carbon position 4 to 13 of said fatty acid is replaced with oxygen.

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