Method of inhibiting photoaging of skin

Details Method of inhibiting photoaging of skin Method of inhibiting photoaging of skin

A - Human Necessities

61

K

A61K 8/58 (2006.01) A61K 8/67 (2006.01) A61K 31/00 (2006.01) A61K 31/16 (2006.01) A61K 31/203 (2006.01) A61K 31/352 (2006.01) A61K 31/381 (2006.01) A61K 31/4045 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2241981

Photoaging of undamaged skin due to UVB irradiation exposure is inhibited by administering an agent that inhibits at least one of (1) the activity of UVB irradiation inducible MMPs in the skin, (2) one or both of the transcription factors AP-1 and NF-.lambda.B or (3) at least one of the GTP binding proteins or kinases involved in the activation and/or production of jun or fos proteins that comprise AP-1; and topically administering said inhibitor to the skin prior to such exposure.

On inhibe le photoviellissement d'une peau sans lésions dû à une exposition aux rayons UVB en administrant un agent qui inhibe au moins (1) l'activité des métalloprotéinases matricielles interstitielles (MMP) pouvant être induites par les rayons UVB sur la peau, et/ou (2) un ou les deux facteurs de transcription AP-1 et/ou NF-b; et/ou (3) au moins une des protéines de liaison GTP ou kinases intervenant dans l'activité et/ou la production des protéines jun ou fos qui comprennent AP-1; et en appliquant localement cet inhibiteur sur la peau avant l'exposition.

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