Method of inhibiting replication of hyperproliferative cells

Details Method of inhibiting replication of hyperproliferative cells Method of inhibiting replication of hyperproliferative cells

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C07K 14/82 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2147127

This invention relates to methods for converting a pathologic hyperproliferative human cell to its non-malignant pheno- type. The method comprises introducing into the cell a nucleic acid encoding a polypeptide having adenovirus E1A activity and growing the cellunder conditions such that the polypeptide is produced. This invention also relates to a method of converting a population of pathologic hyperproliferative cells in a subject to a non-hyperproliferative state by expressing, in some but not all of the hyperproliferative cells, an isolated nucleic acid sequence encoding a polypeptide having adenovirus E1A activity. In a fur- ther aspect, the invention relates to promoting differentiation of pathologically hyperproliferative cells.

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