Method of inhibiting smooth muscle cell proliferation

Details Method of inhibiting smooth muscle cell proliferation Method of inhibiting smooth muscle cell proliferation

C - Chemistry, Metallurgy

12

N

C12N 5/077 (2010.01) A61K 38/45 (2006.01) C12N 15/54 (2006.01) G01N 33/566 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2267694

The present invention relates, in general, to vascular smooth muscle proliferation and, in particular, to a method of inhibiting arterial and venous smooth muscle proliferation resulting, for example, from arterial injury or vein grafting. The invention also relates to an expression construct encoding a G.beta..gamma. inhibitor suitable for use in such a method.

La présente invention se rapporte, de manière générale, à la prolifération des cellules des muscles vasculaires lisses, à un procédé visant à inhiber la prolifération des muscles lisses veineux et artériels se manifestant, par exemple, à la suite d'une blessure artérielle ou d'une greffe de veine. L'invention se rapporte également à un produit d'expression recombiné codant un inhibiteur de G.beta..gamma. adapté à la mise en oeuvre dudit procédé.

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