C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 16/00 (2006.01) C12N 15/10 (2006.01) C12N 15/13 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2219774
One aspect of the invention relates to a phage-display library that expresses single-chain recombinant binding proteins. Inserts in the library comprise immunoglobulin heavy chain framework regions flanking highly divergent, synthetically produced hypervariable regions. A second aspect of the invention relates to the use of single-chain recombinant binding proteins to inhibit the activity of an intracellular constituent. In the exemplary case presented, the activity of intracellular glucose-6-phosphate dehydrogenase was inhibited by intracellular expression of a cloned single-chain recombinant binding protein.
Cette invention concerne, sous l'un de ses aspects, une banque d'affichage de phages, laquelle exprime des protéines de liaison recombinées monocaténaires. Les inserts de cette banque comprennent des régions de structure à chaînes lourdes d'ummunoglobuline bordant des régions hypervariables, produites synthétiquement et hautement divergentes. Sous un second aspect, cette invention concerne l'utilisation de protéines de liaison recombinées monocaténaires afin d'inhiber l'activité d'un constituant intracellulaire. Dans le cas présenté comme exemple, l'activité de glucose-6-phosphate déshydrogénase intracellulaire a pu être inhibée par l'expression intracellulaire d'une protéine de liaison recombinée monocaténaire clonée.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Fetherstonhaugh & Co.
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