A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/220
A61K 31/52 (2006.01)
Patent
CA 1334508
A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula Image (I) in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals other than a 3-methyl-3-hydroxy butyl radi- cal, 3-methyl-3-hydroxy pentyl radical, or 4-methyl-4-hydroxy pentyl radical, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. The inhibition of IL-1, TNF, and other cytokines in mammals is impli- cated in alleviation of a wide variety of disease conditions.
585678
Mandell Gerald L.
Novick William J. Jr.
Sullivan Gail W.
Hoechst Marion Roussel Inc.
Kirby Eades Gale Baker
Mandell Gerald L.
Novick William J. Jr.
Sullivan Gail W.
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