Method of inhibiting vascular permeability

Details Method of inhibiting vascular permeability Method of inhibiting vascular permeability

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01) A61P 9/14 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2513027

The present invention provides a method of regulating vascular permeability. A peptide inhibitor of p21-activated kinase has been found to inhibit the increase in vascular permeability induced by several factors. The present invention further provides methods of identifying regulators of vascular permeability. This peptide or other p21-activated kinase inhibitors should therefore be useful to treat disorders where vascular leak is a contributing factor.

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