Method of inhibition of leukemic stem cells

Details Method of inhibition of leukemic stem cells Method of inhibition of leukemic stem cells

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/02 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2706337

A method for inhibition of leukemic stem cells expressing IL-3R.alpha.; (CD 123), comprises contacting the cells with an antigen binding molecule comprising a Fc region or a modified Fc region having enhanced Fc effector function, wherein the antigen binding molecule binds selectively to IL-3R.alpha. (CD123). The invention includes the treatment of a hematologic cancer condition in a patient by administration to the patient of an effective amount of the antigen binding molecule.

La présente invention concerne un procédé d'inhibition de cellules souches leucémiques exprimant IL-3Ra (CD 123), qui comprend la mise en contact des cellules avec une molécule de liaison à l'antigène comprenant une région Fc ou une région Fc modifiée ayant une fonction effectrice induite par Fc améliorée, la molécule de liaison à l'antigène se liant sélectivement à IL-3Ra (CD123). L'invention concerne le traitement d'un cancer hématologique chez un patient par administration au dit patient d'une quantité efficace de la molécule de liaison à l'antigène.

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